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![]() 研究者DBへ |
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注意:各教員のメールアドレスは“@”マークを“★”にかえてあります |
メッセージ |
糖尿病研究、特に膵b細胞に関する基礎的、臨床的研究を保健学研究科・医学研究科の連携のもとで進めていきたいと考えています。 |
研究テーマ |
膵β細胞量の調節機構の解明 |
社会活動 |
日本糖尿病学会学術評議員、日本内分泌学会評議員、日本病態栄養学会学術評議員 |
最近の主な著書 |
アジアにおける糖尿病 [アジアにおける国際保健],木戸良明(宇賀昭二編),神戸大学国際保健教育研究センター,119-130,2012 看護のための最新医学講座 第31巻 医学と分子生物学 [代謝・内分泌疾患 糖尿病 膵B細胞],木戸良明(小島至、北村聖編),中山書店,263-266,2003 Advances in Molecular and Cellular Endocrinology.Vol.13.[Targeted mutations in the insulin signaling unravel the genetics of diabetes mellitus and growth in mice.] Accili D, Kido Y (ed by LeRoith D). JAI Press Inc.1999 103-118 |
最近の主な論文 |
Asahara S, Etoh H, Inoue H, Teruyama K, Shibutani Y, Ihara Y, Kawada Y, Bartolome A, Hashimoto N, Matsuda T, Koyanagi-Kimura M, Kanno A, Hirota Y, Hosooka T, Nagashima K, Nishimura W, Inoue H, Matumoto M, Higgins MJ, Yasuda K, Inagaki N, Seino S, Kasuga M, Kido Y. Paternal allelic mutation at the Kcnq1 locus reduces pancreatic β cell mass via epigenetic modification of Cdkn1c. Proc Natl Acad Sci USA. 2015 112: 8332-8337 Bartolomé A, Kimura-Koyanagi M, Asahara S, Guillén C, Inoue H, Teruyama K, Shimizu S, Kanno A, Garcéa-Aguilar A, Koike M, Uchiyama Y, Benito M, Noda T, Kido Y. Pancreatic β cell failure mediated by mTORC1 hyperactivity and autophagic impairment. Diabetes. 2014 63: 2996-3008 Matsuda T, Kido Y, Asahara S, Kaisho T, Tanaka T, Hashimoto N, Shigeyama Y, Takeda A, Inoue T, Shibutani Y, Koyanagi M, Hosooka T, Matsumoto M, Inoue H, Uchida T, Koike M, Uchiyama Y, Akira S, Kasuga M.Ablation of C/EBP alleviates ER stress and pancreatic cell failure through the GRP78 chaperone in mice.J Clin Invest.2010 120:115-126 Shigeyama Y, Kobayashi T, Kido Y, Hashimoto N, Asahara S, Matsuda T, Takeda A, Inoue T, Shibutani Y, Koyanagi M, Uchida T, Inoue M, Hino O, Kasuga M, Noda T.Biphasic response of pancreatic cell mass to ablation of TSC2 in mice.Mol Cell Biol 2008 28:2971-2979 Hashimoto N, Kido Y, Uchida T, Asahara S, Shigeyama Y, Matsuda T, Takeda A, Tsuchihashi D, Nishizawa A, Ogawa W, Fujimoto Y, Okamura H, Arden KC, Herrera PL, Noda T, Kasuga M.Ablation of PDK1 in pancreatic cells induces diabetes as a result of loss of -cell mass.Nat Genet.2006 38:589-593 Hashimoto N, Kido Y, Uchida T, Matsuda T, Suzuki K, Inoue H, Matsumoto M, Ogawa W, Maeda S, Fujihara H, Ueta Y, Uchiyama Y, Akimoto K, Ohno S, Noda T, Kasuga M.PKCλ regulates glucose-induced insulin secretion through modulation of gene expression in pancreatic cells.J Clin Invest.2005 115:138-145 Kido Y, Burks DJ, Withers D, Bruning JC, Kahn CR, White MF, Accili D.Tissue-specific insulin resistance in mice with mutations in the insulin receptor, IRS-1, and IRS-2.J Clin Invest.2000 105:199-205 |